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1

Senolytics and senostatics as adjuvant tumour therapy

Short, Susan, Fielder, Edward, Miwa, Satomi, von Zglinicki, Thomas

Journal:

Year:

2019

Language:

english

File:

PDF, 831 KB

english, 2019

2

Oxidative stress shortens telomeres

Thomas von Zglinicki

Journal:

Trends in Biochemical Sciences

Year:

2002

Language:

english

File:

PDF, 88 KB

english, 2002

3

Telomere length predicts poststroke mortality, dementia, and cognitive decline

Carmen Martin-Ruiz, Heather O. Dickinson, Barbara Keys, Elise Rowan, Rose Anne Kenny, Thomas Von Zglinicki

Journal:

Annals of Neurology

Year:

2006

Language:

english

File:

PDF, 116 KB

english, 2006

4

Cellular senescence: unravelling complexity

João F. Passos, Cedric Simillion, Jennifer Hallinan, Anil Wipat, Thomas von Zglinicki

Journal:

Year:

2009

Language:

english

File:

PDF, 281 KB

english, 2009

5

DNA damage response and cellular senescence in tissues of aging mice

Chunfang Wang, Diana Jurk, Mandy Maddick, Glyn Nelson, Carmen Martin-Ruiz, Thomas Von Zglinicki

Journal:

Year:

2009

Language:

english

File:

PDF, 1.34 MB

english, 2009

6

Telomeres: Influencing the Rate of Aging

THOMAS VON ZGLINICKI

Journal:

Annals of the New York Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 106 KB

english, 1998

7

Telomere Length As a Marker of Oxidative Stress in Primary Human Fibroblast Cultures

VIOLETA SERRA, TILMAN GRUNE, NICOLLE SITTE, GABRIELE SARETZKI, THOMAS VON ZGLINICKI

Journal:

Annals of the New York Academy of Sciences

Year:

2000

Language:

english

File:

PDF, 1.06 MB

english, 2000

8

Role of Oxidative Stress in Telomere Length Regulation and Replicative Senescence

THOMAS VON ZGLINICKI

Journal:

Annals of the New York Academy of Sciences

Year:

2000

Language:

english

File:

PDF, 2.79 MB

english, 2000

9

Replicative Aging, Telomeres, and Oxidative Stress

GABRIELE SARETZKI, THOMAS VON ZGLINICKI

Journal:

Annals of the New York Academy of Sciences

Year:

2002

Language:

english

File:

PDF, 201 KB

english, 2002

10

A DNA damage checkpoint response in telomere-initiated senescence

Fagagna, Fabrizio d'Adda di, Reaper, Philip M., Clay-Farrace, Lorena, Fiegler, Heike, Carr, Philippa, von Zglinicki, Thomas, Saretzki, Gabriele, Carter, Nigel P., Jackson, Stephen P.

Journal:

Year:

2003

Language:

english

File:

PDF, 515 KB

english, 2003

11

Telomere-driven replicative senescence is a stress response

Zglinicki, Thomas von, Petrie, Joanne, Kirkwood, Thomas B.L.

Journal:

Nature Biotechnology

Year:

2003

Language:

english

File:

PDF, 264 KB

english, 2003

12

Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes

O Toussaint, E.E Medrano, T von Zglinicki

Journal:

Experimental Gerontology

Year:

2000

Language:

english

File:

PDF, 210 KB

english, 2000

13

A senescent cell bystander effect: senescence-induced senescence

Glyn Nelson, James Wordsworth, Chunfang Wang, Diana Jurk, Conor Lawless, Carmen Martin-Ruiz, Thomas von Zglinicki

Journal:

Year:

2012

Language:

english

File:

PDF, 619 KB

english, 2012

14

A life course approach to healthy ageing: The HALCyon programme

D. Kuh, R. Cooper, M. Richards, C. Gale, T. von Zglinicki, J. Guralnik

Journal:

Year:

2012

Language:

english

File:

PDF, 119 KB

english, 2012

15

DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?

Passos, J. F., Saretzki, G., von Zglinicki, T.

Journal:

Nucleic Acids Research

Year:

2007

Language:

english

File:

PDF, 223 KB

english, 2007

16

Endometriosis is associated with aberrant endometrial expression of telomerase and increased telomere length

Hapangama, D.K., Turner, M.A., Drury, J.A., Quenby, S., Saretzki, G., Martin-Ruiz, C., Von Zglinicki, T.

Journal:

Human Reproduction

Year:

2008

Language:

english

File:

PDF, 789 KB

english, 2008

17

Reference Module in Biomedical Sciences || Aging and Telomeres

von Zglinicki, T.

Year:

2014

Language:

english

File:

PDF, 1.19 MB

english, 2014

18

The epigenetic clock and telomere length are independently associated with chronological age and mortality

Marioni, Riccardo E, Harris, Sarah E, Shah, Sonia, McRae, Allan F, von Zglinicki, Thomas, Martin-Ruiz, Carmen, Wray, Naomi R, Visscher, Peter M, Deary, Ian J

Journal:

International Journal of Epidemiology

Year:

2016

Language:

english

File:

PDF, 478 KB

english, 2016

19

Health and disease in 85 year olds: baseline findings from the Newcastle 85+ cohort study

Collerton, J., Davies, K., Jagger, C., Kingston, A., Bond, J., Eccles, M. P, Robinson, L. A, Martin-Ruiz, C., von Zglinicki, T., James, O. F W, Kirkwood, T. B L

Journal:

Year:

2009

Language:

english

File:

PDF, 174 KB

english, 2009

20

The epigenetic clock and telomere length are independently associated with chronological age and mortality

Marioni, Riccardo E, Harris, Sarah E, Shah, Sonia, McRae, Allan F, von Zglinicki, Thomas, Martin-Ruiz, Carmen, Wray, Naomi R, Visscher, Peter M, Deary, Ian J

Journal:

International Journal of Epidemiology

Year:

2017

Language:

english

File:

PDF, 219 KB

english, 2017

21

Mitochondria and ageing: winning and losing in the numbers game

João F. Passos, Thomas von Zglinicki, Thomas B.L. Kirkwood

Journal:

Year:

2007

Language:

english

File:

PDF, 166 KB

english, 2007

22

Mitochondrial water loss and aging of cells

T. Von Zglinicki, C. Schewe

Journal:

Cell Biochemistry and Function

Year:

1995

Language:

english

File:

PDF, 938 KB

english, 1995

23

Tumour-cell apoptosis after cisplat in treatment is not telomere dependent

Jessie C. Jeyapalan, Gabriele Saretzki, Alan Leake, Michael J. Tilby, Thomas von Zglinicki

Journal:

International Journal of Cancer

Year:

2006

Language:

english

File:

PDF, 934 KB

english, 2006

24

Schlieren optical imaging of weak objects

Thomas von Zglinicki, Stephan Heymann

Journal:

Year:

1969

Language:

english

File:

PDF, 2.49 MB

english, 1969

25

Mechanisms and role of oxidative damage to telomeres

Joao Passos, Torsten Richter, Gabriele Saretzki, Thomas von Zglinicki

Journal:

Year:

2006

Language:

english

File:

PDF, 76 KB

english, 2006

26

A mitochondrial membrane hypothesis of aging

Thomas von Zglinicki

Journal:

Journal of Theoretical Biology

Year:

1987

Language:

english

File:

PDF, 430 KB

english, 1987

27

MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress

Gabriele Saretzki, Michael P. Murphy, Thomas Von Zglinicki

Journal:

Year:

2003

Language:

english

File:

PDF, 193 KB

english, 2003

28

Capability and dependency in the Newcastle 85+ cohort study. Projections of future care needs

Carol Jagger, Joanna C Collerton, Karen Davies, Andrew Kingston, Louise A Robinson, Martin P Eccles, Thomas von Zglinicki, Carmen Martin-Ruiz, Oliver FW James, Tom BL Kirkwood, John Bond

Journal:

Year:

2011

Language:

english

File:

PDF, 291 KB

english, 2011

29

The Newcastle 85+ study: biological, clinical and psychosocial factors associated with healthy ageing: study protocol

Joanna Collerton, Karen Barrass, John Bond, Martin Eccles, Carol Jagger, Oliver James, Carmen Martin-Ruiz, Louise Robinson, Thomas von Zglinicki, Tom Kirkwood

Journal:

Year:

2007

Language:

english

File:

PDF, 512 KB

english, 2007

30

Telomeres, cell senescence and human ageing

Thomas von Zglinicki, Carmen M. Martin-Ruiz, Gabriele Saretzki

Journal:

Signal Transduction

Year:

2005

Language:

english

File:

PDF, 97 KB

english, 2005

31

An Important Role for CDK2 in G1 to S Checkpoint Activation and DNA Damage Response in Human Embryonic Stem Cells

Irina Neganova, Felipe Vilella, Stuart P. Atkinson, Maria Lloret, João F. Passos, Thomas von Zglinicki, José-Enrique O'Connor, Deborah Burks, Richard Jones, Lyle Armstrong, Majlinda Lako

Journal:

Year:

2011

Language:

english

File:

PDF, 1.86 MB

english, 2011

32

Localization artefacts in ultracytochemical ion precipitation reactions

T. Von Zglinicki, K. Punkt

Journal:

Journal of Molecular Histology

Year:

1986

Language:

english

File:

PDF, 2.93 MB

english, 1986

33

Association of mitochondrial haplogroup J and mtDNA oxidative damage in two different North Spain elderly populations

Elena Domínguez-Garrido, Diana Martínez-Redondo, Carmen Martín-Ruiz, Aurora Gómez-Durán, Eduardo Ruiz-Pesini, Pilar Madero, Manuel Tamparillas, Julio Montoya, Thomas von Zglinicki, Carmen Díez-Sánchez

Journal:

Year:

2009

Language:

english

File:

PDF, 226 KB

english, 2009

34

Lymphocyte telomere dynamics and telomerase activity in inflammatory bowel disease: effect of drugs and smoking

K. M. Getliffe, D. Al Dulaimi, C. Martin-Ruiz, R. L. Holder, T. Von Zglinicki, A. Morris, C. U. Nwokolo

Journal:

Alimentary Pharmacology & Therapeutics

Year:

2005

Language:

english

File:

PDF, 187 KB

english, 2005

35

Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study

Carmen M. Martin-Ruiz, Jacobijn Gussekloo, Diana van Heemst, Thomas von Zglinicki, Rudi G. J. Westendorp

Journal:

Year:

2005

Language:

english

File:

PDF, 91 KB

english, 2005

36

No association between socio-economic status and white blood cell telomere length

Jean Adams, Carmen Martin-Ruiz, Mark S. Pearce, Martin White, Louise Parker, Thomas Von Zglinicki

Journal:

Year:

2007

Language:

english

File:

PDF, 60 KB

english, 2007

37

Architectural changes in the thymus of aging mice

Danielle Aw, Alberto B. Silva, Mandy Maddick, Thomas Von Zglinicki, Donald B. Palmer

Journal:

Year:

2008

Language:

english

File:

PDF, 352 KB

english, 2008

38

Mitochondrial turnover in liver is fast in vivo and is accelerated by dietary restriction: application of a simple dynamic model

Satomi Miwa, Conor Lawless, Thomas Von Zglinicki

Journal:

Year:

2008

Language:

english

File:

PDF, 1.00 MB

english, 2008

39

Fat tissue, aging, and cellular senescence

Tamara Tchkonia, Dean E. Morbeck, Thomas Von Zglinicki, Jan Van Deursen, Joseph Lustgarten, Heidi Scrable, Sundeep Khosla, Michael D. Jensen, James L. Kirkland

Journal:

Year:

2010

Language:

english

File:

PDF, 338 KB

english, 2010

40

Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation

Vanja Pekovic, Ian Gibbs-Seymour, Ewa Markiewicz, Fahad Alzoghaibi, Adam M. Benham, Robert Edwards, Manfred Wenhert, Thomas von Zglinicki, Christopher J. Hutchison

Journal:

Year:

2011

Language:

english

File:

PDF, 636 KB

english, 2011

41

Telomere shortening in human fibroblasts is not dependent on the size of the telomeric-3′-overhang

Barbara Keys, Violeta Serra, Gabriele Saretzki, Thomas Von Zglinicki

Journal:

Year:

2004

Language:

english

File:

PDF, 265 KB

english, 2004

42

Similar Gene Expression Patterns in Senescent and Hyperoxically Blocked Fibroblasts

GABRIELE SARETZKI, THOMAS VON ZGLINICKI, BRYANT VILLEPONTEAU

Journal:

Annals of the New York Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 30 KB

english, 1998

43

The Relationship between the Aging- and Photo-Dependent T414G Mitochondrial DNA Mutation with Cellular Senescence and Reactive Oxygen Species Production in Cultured Skin Fibroblasts

Birket, Matthew J, Passos, João F, von Zglinicki, Thomas, Birch-Machin, Mark A

Journal:

The Journal of Investigative Dermatology

Year:

2008

Language:

english

File:

PDF, 467 KB

english, 2008

44

Short Telomeres in Patients with Vascular Dementia: An Indicator of Low Antioxidative Capacity and a Possible Risk Factor?

von Zglinicki, Thomas, Serra, Violeta, Lorenz, Mario, Saretzki, Gabriele, Lenzen-Groβimlighaus, Romana, Geβner, Reinhard, Risch, Angela, Steinhagen-Thiessen, Elisabeth

Journal:

Laboratory Investigation

Year:

2000

Language:

english

File:

PDF, 286 KB

english, 2000

45

Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells

Saretzki, Gabriele, Ludwig, Antje, von Zglinicki, Thomas, Runnebaum, Ingo B

Journal:

Cancer Gene Therapy

Year:

2001

Language:

english

File:

PDF, 322 KB

english, 2001

46

Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments

Saretzki, Gabriele, Sitte, Nicolle, Merkel, Ulrike, Wurm, Reinhard E, von Zglinicki, Thomas

Journal:

Year:

1999

Language:

english

File:

PDF, 806 KB

english, 1999

47

Lysosomal Redox-Active Iron Is Important for Oxidative Stress-Induced DNA Damage

TINO KURZ, ALAN LEAKE, THOMAS VON ZGLINICKI, ULF T. BRUNK

Journal:

Annals of the New York Academy of Sciences

Year:

2004

File:

PDF, 745 KB

2004

48

Telomere length and anaemia in old age: results from the Newcastle 85-plus Study and the Leiden 85-plus Study

Den Elzen, W. P. J., Martin-Ruiz, C., von Zglinicki, T., Westendorp, R. G. J., Kirkwood, T. B. L., Gussekloo, J.

Journal:

Year:

2011

Language:

english

File:

PDF, 243 KB

english, 2011

49

Overexpression of Telomerase Confers Growth Advantage, Stress Resistance, and Enhanced Differentiation of ESCs Toward the Hematopoietic Lineage

L. Armstrong, G. Saretzki, H. Peters, I. Wappler, J. Evans, N. Hole, T. von Zglinicki, M. Lako

Journal:

Year:

2005

Language:

english

File:

PDF, 459 KB

english, 2005

50

Downregulation of Multiple Stress Defense Mechanisms During Differentiation of Human Embryonic Stem Cells

Gabriele Saretzki, Theresia Walter, Stuart Atkinson, Jõao F. Passos, Bettina Bareth, W. Nicol Keith, Rebecca Stewart, Stacey Hoare, Miodrag Stojkovic, Lyle Armstrong, Thomas von Zglinicki, Majlinda La

Journal:

Year:

2008

Language:

english

File:

PDF, 2.80 MB

english, 2008